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-synuclein, which can be a most important component of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which is an E3 ubiquitin ligase and brings about endoplasmic reticulum (ER) pressure, recommend that dysfunction on the intracellular proteinase devices, which include ubiquitin-proteasome method or lysosomal system, which removes nee

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